Use of Supercritical Fluid Chromatography to Improve Efficiency of Medicinal Chemistry Purifications
Posted on March 20, 2014
By: Larry Miller, Principal Scientist; Shawn J. Ayube, Senior Associate Scientist,
Amgen
Abstract Supercritical Fluid Chromatography (SFC) is a chromatographic technique used for small molecule analysis and purification. In SFC a carbon dioxide based mobile phase is utilised. The low viscosity and high diffusivity of carbon dioxide allows higher flowrates than HPLC. In addition carbon ...
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Related Topics and Keywords
Amgen, chiral purification, chromatography, HPLC, Rapid Analytical Method, SFC, supercritical fluid chromatography
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