Pharmaceutical Hot Melt Extrusion A Cost Effective Method to Increase Solubility

07th May 2019 | 9:00 am EST/ 14:00 GMT/ 15:00 CET | Dennis Douroumis, Professor in Pharmaceutical Technology and Process Engineering at University of Greenwich and Dr.-Ing Margarethe Richter, Pharma Application Specialist at Thermo Fisher Scientific |WATCH FOR FREE

• Identifying the appropriate excipients for HME processing of water insoluble drugs
• Using novel excipients to achieve increased dissolution rates (Granulation)
• Extrusion with polymeric carriers for the development of solid dispersions
• Co-crystallisation of water insoluble drugs

In the last 20 years Hot Melt Extrusion (HME) has seized the attention of pharmaceutical industry for the development of pharmaceutical solid dispersions. It is a versatile processing technology, which can effectively increase the solubility/dissolution of water insoluble active pharmaceutical ingredients (APIs). The processing of a wide range of materials including inorganic excipients, hydrophilic polymers or cocrystal formers renders HME advantageous compared to conventional formulation technologies. In this review article we discuss recent trends for increased solubility/dissolution of water insoluble actives by using HME and predictive tools for process optimisation.

Presented by Dennis Douroumis, Professor in Pharmaceutical Technology and Process Engineering at University of Greenwich

Dr. Dennis Douroumis is a Professor in Pharmaceutical Technology and Process Engineering at the Universities of Kent and Greenwich. His research focuses on the development and characterization of drug products by using continuous manufacturing processes such as hot melt extrusion and spray-drying. His research also explores the use of Quality by Design (QbD) approaches and Process Analytical Tools (PAT) for process optimization. He has industrial experience on R&D of solid dosage forms, technology transfer and scale-up. Due to his expertise he led several EU funded projects (MultiDES) as the principal investigator and he has established industrial collaborators for the development of extruded products. He is the Head of Medway School of Pharmacy and has joined the Editorial Boards of more than ten international peer reviewed journal including the Wiley’s Editorial Board for the series in “Advances in Pharmaceutical Technology”. He has published more than 120 peer-reviewed publications, including 100 full papers, 4 book chapters and 2 books (Wiley-Blackwell)

Sponsored by Thermo Fisher Scientific

Thermo Fisher Scientific provides reliable extrusion and granulation solutions in pharmaceutical processing. We can help you switch from batch to continuous processing with twin-screw extrusion technology and analytical expertise, and we give scientific support for scale-up of such operations. Our wide range of extruders and granulators, plus our rheometer systems, can help you meet goals faster.

Followed by the webinar: Introduction to Hot Melt Extrusion for Pharmaceutical Applications

Already a well-known process in the polymer industry, HME is now becoming prevalent in pharmaceutical manufacturing for innovative formulations of solid oral dosage forms. Its main advantage in pharmaceutical applications is the ability to enhance bioavailability of a drug, i.e., to produce solid dispersions of the API in the polymer matrix. Improved bioavailability of API is one of the key goals in drug formulation, along with achieving the appropriate release profile (i.e., immediate versus sustained release).

This webinar presentation introduces HME technology as an alternative to the more traditional spray drying method. It includes several case studies related to HME for solid oral dosage forms. In addition to solid oral dosage forms, HME can be used for novel delivery methods. The presentation also provides an overview of possible drug delivery applications including examples and case studies.

By Dr.-Ing Margarethe Richter, Pharma Applications Specialist at Thermo Fisher Scientific

Margarethe Richter is a Pharma Applications Specialist at Thermo Fisher Scientific where she develops new applications for pharmaceutical grade twin-screw extruders. She regularly publishes her findings and provides worldwide support to pharmaceutical customers. Dr. Richter’s expertise includes international experience with HME, twin-screw granulation for various pharmaceutical dosage forms, scale-up and GMP.

Prior to her work at Thermo Fisher Scientific, Dr. Richter was a researcher at the German Aerospace Center (DLR), Institute of Engineering Thermodynamics in Stuttgart, Germany. There she focused on thermochemical energy storage, heat transformation, thermal analysis, and thermodynamic and kinetic reaction models. She earned her PhD degree (Dr.-Ing.) from the University of Stuttgart. In addition, she became a chemical engineer by training after graduating from the Karlsruhe Institute of Technology (KIT).

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