Overcoming Downstream Bottlenecks In The Upscaling Process


17th January 2019 | 9:30 UK Time | Dr. Dakshesh Mehta, Associate Vice President and Head of Bioprocess Group at Biotech & Genomics division, Wockhardt Research Center |BOOK FREE SEAT

In recent years, due to major advances in upstream process, therapeutic proteins can be produced at higher concentrations than ever before. For, these high-titer, high-cell density production, chromatography operations may be as perceived bottlenecks. Column size limitations, low dynamic capacity and buffer volume requirements are generally considered as contributing factors, apart from high resin costs. The talk will cover how flexible manufacturing systems could help establish efficient downstream processes to overcome capacity bottleneck. Also how downstream footprint can be reduced whilst speeding up purification process.  Is there anyway, one could eliminate chromatography operations with other technologies that may require less space and buffers and also may be more cost-effective?

Presented by Dr Dakshesh Mehta, Associate Vice President and Head of Bioprocess Group at Biotech & Genomics division, Wockhardt Research Center

Dr Dakshesh Mehta is currently the Associate Vice President and Head of Bioprocess Group at Biotech & Genomics division, Wockhardt Research Center, Aurangabad. At Wockhardt, he leads a group of process development scientists for development of biosimilar recombinant therapeutic proteins. His responsibilities include DNA construct design for expression, selection of higher producer clones, generation and characterization of cell banks, process development to obtained recombinant proteins with desired quality, technology transfer and scale up to pilot plant, Support to analytical development, manufacturing, Quality and regulatory team. Before joining Wockhardt, Dr. Mehta was working at Aurigene Discovery Technologies, Dr. Reddy’s subsidiary, Bangalore as a Protein Scientist, where he was involved in expression and purification of drug target proteins for structural and functional studies.Dr. Mehta holds a M.Sc. and Ph.D. degree in Biotechnology from IIT, Mumbai with specialization in yeast molecular biology and genetics. He was a post-doctoral fellow at M.D. Anderson Center, Houston, Texas USA and was also a visiting scientist at National Institute of Environmental Health Science, NIH, Research Triangle Park, USA. He has several publications to his credit. Dr. Mehta has been invited as a speaker at various national and international forums.

 


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