In Situ High Speed NIR Imaging & Raman Mapping to Monitor Form Change and Drug Release from Rapidly Disintegrating Tablets

10th March 2020 | 11AM CET / 10AM GMT | Patrick Wray, Senior Research Investigator at Bristol-Myers Squibb and Miriam Böhmler, Senior Applications Scientist at WITec GmbH |WATCH FOR FREE

Spectroscopic imaging is a powerful chemically specific and spatially resolved approach that can be used to effectively monitor tablet dissolution. This work employs Raman mapping and Near Infrared (NIR) chemical imaging to examine drug release from model tablet formulations as complementary technologies. Modern pushbroom type NIR imaging systems allow extremely fast acquisition of chemical images. Consequently, this allows us to study the chemical and physical changes which occur during drug release from rapidly disintegrating formulations.
A custom designed to flow through cell is used to carry out the tablet dissolutions in such a way that the sample is presented to the optics of the chemical imaging system being used. The cell is compatible for use with NIR, Raman and Mid IR spectrometers.
Two types or formulations will be presented: Rapidly disintegrating formulations with varying amounts of super disintegrant and tablets containing a model drug exhibiting fast onset of disproportionation in pH neutral conditions.
The fast NIR imaging system is seen to be capable of monitoring the ingress of water into the tablet and the subsequent disintegration of the formulation. Data from the disproportionating formulations has shown the benefit of chemical imaging to improve our understanding of form change in real time.

Presented by Patrick Wray, Senior Research Investigator at Bristol-Myers Squibb

Patrick Wray is a Senior Research Investigator at Bristol-Myers Squibb where he is a specialist in using vibrational spectroscopy and process analytical technologies to support formulation process understanding.

Before joining Bristol-Myers Squibb Patrick graduated from Imperial College London with a masters in Chemical Engineering. This was then followed by PhD in the same department during which he used ATR-FTIR spectroscopic imaging to study the compaction and dissolution of model pharmaceutical formulations.

Throughout this time he has also made significant use of novel vibrational spectroscopic imaging technologies, enabling enhanced understanding of dissolution processes, disproportionation and amorphous systems characterisation. This has required the development of custom experimental apparatus and data processing software. He has published multiple papers and a book chapter in this field.

Followed by Cutting-edge Raman Imaging for New Advances in Pharmaceutics

Confocal Raman imaging microscopy is a non-destructive chemical characterization method based on an energy shift in excitation light scattered by molecules or crystal lattices. This is known as the Raman effect and it can be detected by a spectrometer as a Raman peak within a Raman spectrum, which can serve as a “fingerprint” for individual materials in the sample.
Acquiring a Raman spectra and linking those data points to coordinates on a sample enables the creation of a Raman image, which visualizes the distribution of the chemical components at very high speed and resolution. It does so without altering or damaging even delicate samples, without requiring staining or other specialized sample preparation, and without necessitating large sample volumes or high concentrations.
This webinar will feature a series of measurement examples that will demonstrate the utility of Raman microscopy for pharmaceutical research. These will include an analysis of toothpaste, real-time imaging of drug delivery with inverted Raman microscopy, flow cell Raman analysis, API distribution determination and microplastic characterization and quantification using a Raman microparticle analysis tool, 3D Raman imaging of a cosmetic hand cream, and the identification of components using a Raman spectral database.

Followed by Dr. Miriam Böhmler, Senior Applications Scientist at WITec GmbH

Dr. Miriam Boehmler is a Senior Applications Scientist at WITec GmbH in Ulm, Germany. She possesses wide-ranging expertise in Raman imaging and spectroscopy, near-field and super-resolution optical technologies such as tip-enhanced Raman spectroscopy, and nano-FTIR spectroscopy.

Her specialty within the company is using high-speed confocal Raman microscopy techniques to analyze samples from various fields of application, including pharmaceutics and cosmetics, biology and life science, material science, 2D materials, polymers and many more.
Additional responsibilities include developing and presenting advanced training services to customers during on-site installations and in-house equipment demonstrations. She also provides scientific support to worldwide project partners during technological collaborations.

Dr. Boehmler was awarded a PhD in Chemistry from Ludwig Maximilian University of Munich, Germany, after working on sub-diffraction limited microscopy and spectroscopy (tip-enhanced Raman and photoluminescence spectroscopy). She received the Roemer Prize in 2012 for outstanding research work in the category of doctoral scholarship (Roemer Foundation: Foundation for the Promotion of Chemical and Biochemical Research).

Sponsored by WITec

WITec pioneered 3D Raman imaging and correlative microscopy and continues to lead the industry with a unique product portfolio that offers speed, sensitivity and resolution without compromise. Raman, AFM, SNOM and SEM (RISE) microscopes and select combinations thereof can be configured for specific challenges in chemical and structural characterization.

WITec’s unique confocal Raman microscopes are capable of routinely performing 3D chemical Raman imaging while maintaining the highest measurement speed and spectral quality. This is particularly beneficial for applications in which the exact spatial representation of the chemical components on the surface or within the sample is important. Depth profiles, 3D image stacks or topographic Raman images can be easily created with maximum informational content. The streamlined workflow of the fully integrated hardware and software can greatly accelerate pharmaceutical and life sciences research.

The company’s headquarters is located in Ulm, Germany, where all WITec products are developed and produced. Branch offices in USA, Japan, Singapore, China, France and Spain provide a worldwide sales and support network. WITec’s enduring success and innovative product range have been recognized by a series of significant industry awards.

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