In Situ High Speed NIR Imaging & Raman Mapping to Monitor Form Change and Drug Release from Rapidly Disintegrating Tablets

10th March 2020 | 11AM CET / 10AM GMT | Patrick Wray, Senior Research Investigator at Bristol-Myers Squibb |BOOK FREE SEAT

Spectroscopic imaging is a powerful chemically specific and spatially resolved approach which can be used to effectively monitor tablet dissolution. This work employs Raman mapping and Near Infrared (NIR) chemical imaging to examine drug release from model tablet formulations as complementary technologies. Modern pushbroom type NIR imaging systems allow extremely fast acquisition of chemical images. Consequently this allows us to study the chemical and physical changes which occur during drug release from rapidly disintegrating formulations.
A custom designed flow through cell is used to carry out the tablet dissolutions in such a way that the sample is presented to the optics of the chemical imaging system being used. The cell is compatible for use with NIR, Raman and Mid IR spectrometers.
Two types or formulations will be presented: Rapidly disintegrating formulations with varying amounts of super disintegrant and tablets containing a model drug exhibiting fast onset of disproportionation in pH neutral conditions.
The fast NIR imaging system is seen to be capable of monitoring ingress of water into the tablet and the subsequent disintegration of the formulation. Data from the disproportionating formulations has shown the benefit of chemical imaging to improve our understanding of form change in real time.

Presented by Patrick Wray, Senior Research Investigator at Bristol-Myers Squibb

Patrick Wray is a Senior Research Investigator at Bristol-Myers Squibb where he is a specialist in using vibrational spectroscopy and process analytical technologies to support formulation process understanding.

Before joining Bristol-Myers Squibb Patrick graduated from Imperial College London with a masters in Chemical Engineering. This was then followed by PhD in the same department during which he used ATR-FTIR spectroscopic imaging to study the compaction and dissolution of model pharmaceutical formulations.

Throughout this time he has also made significant use of novel vibrational spectroscopic imaging technologies, enabling enhanced understanding of dissolution processes, disproportionation and amorphous systems characterisation. This has required the development of custom experimental apparatus and data processing software. He has published multiple papers and a book chapter in this field.

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