HME lipidic Pellets for Paediatric Application. An Investigation of the Effect and Stability on Drug Dissolutions


11th June 2019 | 10.00 am EST | Dennis Douroumis, Professor in Pharmaceutical Technology and Process Engineering at University of Greenwich |WATCH FOR FREE

Hot Melt Extrusion (HME) is an established processing technology that can be used for the development of paediatric formulations. The processing of lipids via HME has been proved ideal for high drug loaded dosage forms with sustained release of drugs. The study investigates the effect of the lipid type and the food grade on the dissolution rates of extruded pellets or extemporaneous formulations. The stability of lipidic formulations is a very important aspect especially for paediatric applications. Here the stability of various formulations comprising of GRAS excipients is also examined.

Presented by Dennis Douroumis, Professor in Pharmaceutical Technology and Process Engineering at University of Greenwich


Dr. Dennis Douroumis is a Professor in Pharmaceutical Technology and Process Engineering at the Universities of Kent and Greenwich. His research focuses on the development and characterization of drug products by using continuous manufacturing processes such as hot melt extrusion and spray-drying. His research also explores the use of Quality by Design (QbD) approaches and Process Analytical Tools (PAT) for process optimization. He has industrial experience on R&D of solid dosage forms, technology transfer and scale-up. Due to his expertise he led several EU funded projects (MultiDES) as the principal investigator and he has established industrial collaborators for the development of extruded products. He is the Head of Medway School of Pharmacy and has joined the Editorial Boards of more than ten international peer reviewed journal including the Wiley’s Editorial Board for the series in “Advances in Pharmaceutical Technology”. He has published more than 120 peer-reviewed publications, including 100 full papers, 4 book chapters and 2 books (Wiley-Blackwell)


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