Xcellerex XDR-50 MO – GE Healthcare Life Sciences

Stirring up the fermentation game The adoption of single-use technology by biomanufacturers using microbial systems has been inhibited by the lack of single-use bioreactor systems capable of accommodating the unique requirements of microbial cultures. Bioreactors designed for production in mammalian culture fall short of meeting these requirements, for example in terms of oxygen transfer capacity and temperature control. The Xcellerex XDR-50 MO fermentor system is purpose-designed and built to overcome the mammalian single-use system limitations in fulfilling these needs. The XDR-50 MO system design supports high mass transfer, reliable temperature control, and excellent gas dispersion—all with the added benefits of single-use technology. The fermentor is well-suited for process development and seed-train applications. • Modular, single-use stirred-tank fermentor • Jacketed vessel for efficient heat-transfer • Two-stage, magnetically coupled impeller • User-friendly automation system that integrates with legacy automation platforms • Impeller, aspect ratio, and baffle design optimized for microbial fermentation • Minimizes the need for costly and time-consuming cleaning-in-place and cleaning validation procedures Visit www.gelifesciences.com/xdr-50mo to learn more and to download an application note describing the performance of a single-use Xcellerex XDR-50 bioreactor system when used in cultivations of Escherichia coli (E. coli) and of modified Pseudomonas fluorecsens (P. fluorescens) producing a monoclonal antibody (MAb). The XDR-50 MO fermentor is part of Xcellerex scalable, single-use bioreactor family for working volumes ranging from 4.5 L to 2000 L. The system design of XDR stirred-tank bioreactors enables easy scaling and facilitates the achievement of a robust, final manufacturing-scale process.

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