Lonza’s QC Testing Solutions: Endotoxin Detection Expertise and Commitment to Sustainability

For endotoxin detection, Lonza offers Limulus Amebocyte Lysate (LAL), a reagent derived from blood cells of the horseshoe crab. Lonza’s endotoxin detection products are used to perform the LAL test, an Endotoxin Detection Quality Control test on raw, in-process and final release materials. The LAL test helps ensure that human and animal intravenous drugs, vaccines and medical devices are safe for use. Lonza has been providing endotoxin detection products and services since the 1970s, adapting its offerings and services to the needs of customers and to changing technologies. In 2003, Lonza brought to market the PyroGene™ recombinant Factor C Assay, an endotoxin detection method that does not rely on the use of horseshoe crab blood as the raw material.

Accepted by the FDA, European Pharmacopeia and other leading regulatory authorities, the recombinant Factor C method is a recognized, comparable endotoxin detection method to LAL-based assays. Based on the activation of a recombinant form of Factor C, the first component in the horseshoe crab clotting cascade, the PyroGene™ recombinant Factor C Assay offers the same reliability as an LAL method – without the use of animal resources.

Lonza is committed to help protect future generations of the horseshoe crab and invites professionals to subscribe to their quarterly, free QC Testing Solutions e-Newsletter.

For each subscription, Lonza donates $1.00 to the Ecological Research & Development group (ERDG), a non-profit wildlife conservation organization whose primary focus is the conservation of the world’s four remaining horseshoe crab species.

To learn more on how to use PyroGene™ Assay as a sustainable LAL alternative visit www.lonza.com/pyrogene

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