FT-NIR Solutions for increased manufacturing efficiency – Bruker

The production of pharmaceutical products is a chain of different engineering processes – from setting up the formulation to granulating, drying, mixing, tabletting, coating and packaging the finished product. Only a totally error-free progression through each of the single steps guarantees a product of sufficient quality. Ideally, quality control would be introduced not only after, but also during, the manufacturing process. PAT concentrates in particular on FT-NIR spectroscopy as the most important analytical procedure for the in-line control, as FT-NIR is unrivalled in the sum of its possibilities. Bruker offers a wide range of PAT enabling solutions, which meet the pharmaceutical industries analytical requirements as well as the stringent validation and regulatory requirements: • The MPA is the ideal QA/QC tool for incoming goods control or tablet testing in the lab. • The MATRIX-F process spectrometer with its internal 6 multiplexer adapts to every process utilising different probes, flow cells and contactless measurement heads – with full OPC connectivity or easy process implementation via “Dynamic Link Libraries”. • The TANDEM is an online analysis system developed for the pharmaceutical tablet production to measure specifically as the active ingredient and humidity levels in addition to the physical parameters such as weight, thickness, diameter and hardness e.g. used for compression machine control. All Bruker spectrometers are designed for reliability and easy maintenance. The instrument can be serviced quickly with user-exchangeable consumable components for minimal disruption of the manufacturing process. www.bruker.com

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