Capto™ Core 700 – GE Healthcare Life Sciences

Capto Core 700 is designed for intermediate purification and polishing of viruses and other large biomolecules. The novel core bead technology is composed of a ligand-activated core and inactive shell. The inactive shell excludes large molecules (cut off ~ Mr 700000 [700 kDa]) from entering the core through the pores of the shell. These larger molecules are collected in the column flowthrough while smaller impurities bind to the internalised ligands. The core of each bead is functionalised with ligands that are both hydrophobic and positively charged, resulting in a highly efficient multimodal binding of various contaminants small enough to enter the core. The multimodal ligands ensure strong binding with most impurities over a wide range of pH and salt concentrations. Bound impurities are removed from the beads by cleaning-in-place (CIP) procedures. www.gelifesciences.com/captocore

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