Pyrogen Testing in the 21st Century
Posted on May 20, 2025
Ingo Spreitzer, Deputy Head, Division Microbiology, Section 1/3 “Microbial Safety”, Paul-Ehrlich-Institut, Langen, Germany
Abstract The rabbit pyrogen test (RPT) was introduced into the British Pharmacopoeia in 1912, and 1942 into the United States Pharmacopeia. Since then both the predictive RPT and improved pharmaceutical manufacturing led to the safety level expected nowadays. Frequently the RPT has been replaced by ...
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