Near-infrared Spectroscopy for Monitoring Maillard Reaction and Critical Process Parameters of a C. Tetani Bioprocess
Posted on August 16, 2021
Paper Authors Gabriella Gerzon, PhD Candidate, Ricardo Villegas, Upstream Manager, Jessica Duprez, Postdoctoral Fellow, Sudagar Dhaliwal, JFT-NIR and Process Technology Manager, Yi Sheng, Associate Professor, Marina Kirkitadze, Head of Process Support & PAT Platform,
Analytical Sciences, Sanofi Pasteur, Toronto, Canada
York University, Toronto, Canada
Manufacturing Technology, Sanofi Pasteur, Toronto, Canada
York University, Toronto, Canada
Bruker Ltd., Milton, Ontario
York University, Toronto, Canada
Analytical Sciences, Sanofi Pasteur, Toronto, Canada
Abstract Purpose: The goal of the study is to determine if near-infrared spectroscopy (NIR) is a feasible analytical method to monitor in-line process parameters for C. tetani bioprocess monitoring and Maillard reaction. Methods: Off-line NIR measurements were acquired using the Matrix-F and Excalib...
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