Enabling Formulation Approaches for Poorly Soluble Compounds in Early Development
Posted on November 13, 2012
By: Keith Horspool, Vice President Pharmaceutical Development; Chandan Bhugra, Principal Scientist; Anjali Agrawal, Principal Scientist; Sid Mujumdar, Principal Scientist; Chitra Telang, Principal Scientist; Dongmei Qiang, Principal Scientist.
Boehringer Ingelheim Pharmaceuticals
Abstract Combinatorial chemistry and new targets with chemical structure-activity requirements that are less compatible with drug-like properties are resulting in nomination of development candidates with poor aqueous solubility. This, in conjunction with high values for estimated doses in Phase I c...
To read the full article and other articles in this issue, please register for a free account or log in.
We will not sell or give your information to a third party. See our Privacy Policy
Related Topics and Keywords
Boehringer, crystallisation, dissolution, downstream, excipients, Hot melt extrusion, micronisation, nanoparticles, pharmacokinetic, Plasticisers, polymer, Raman, solubilisers, solubility, Spray-drying, XRPD
Subscribe to our FREE newsletter and WEBINAR UPDATES
We will not sell or give your information to a third party. See our Privacy Policy
