Current Status of Analytical Techniques for Characterization of Protein Stability
Posted on February 21, 2018
Sanket Patke
Research Investigator
Drug Product Science and Technology
Bristol-Myers Squibb Co., New Brunswick, NJ
Joshua M. Stillahn
Scientist
Legacy BioDesign, Johnstown, CO
Department of Chemistry, Colorado State University, Fort Collins, CO
Mark Cornell Manning
Chief Scientific Officer
Legacy BioDesign, Johnstown, CO
Department of Chemistry, Colorado State University, Fort Collins, CO
Abstract A major goal of pharmaceutical development is to characterize pathways of chemical and physical instability and develop strategies to minimize them. The potential for the presence of multiple degradation products in protein-based pharmaceuticals highlights a need for analytical methods capa...
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Related Topics and Keywords
ADCs, Analytical Techniques, antibody-drug conjugates, biotherapeutics, Bristol-Myers Squibb Co, characterization, characterize pathways, chemical degradation, Colorado State University, Joshua M. Stillahn, particulate formation, Protein Stability, Sanket Patke, therapeutic proteins
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