Characterisation of Host-Cell Proteins using Mass Spectrometry Enables Effective Purification Optimisation
Posted on March 4, 2016
By: Li Zang, Senior Scientist, Analytical Development
Biogen, Cambridge, MA 02142, USA
Common mammalian cell lines used for biopharmaceutical production include Chinese Hamster Ovary (CHO), NS0 and Human Embryonic Kidney (HEK) cells. Each of these cell lines has been found with over 20,000 genes coded in their genome, which can result in over 10,000 proteins expressed at the same time...
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Related Topics and Keywords
biogen, biopharmaceutical production, biopharmaceutical protein stability, Characterisation of host cell proteins, Chinese Hamster Ovary, CHO, effective purification Optimisation, ELISA, enzyme-linked immunosorbent assay, HCPs, HEK cells, host-cell proteins, Human Embryonic Kidney, LC/MS, Li Zang, liquid chromatography/ mass spectrometry, mammalian cell line, mass spectrometry
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