Bioreactor Process Improvements in a Perfusion-Based Process
Posted on November 8, 2024
Jiayi Zhang, Senior Director CMC, WuXi Biologics
(Previously Manager, Process Development/Engineering, Genzyme)
Gregory Walsh, Associate Director CMSC-MSAT, Vertex Pharmaceuticals
(Previously Associate Director of Manufacturing
Sciences and Technology (MSAT), Genzyme)
Lada Ivana Laenen Horvat, Ph.D., Senior Vice President; Manufacturing Science and Technology, Global Supply Chain Executive, GSK
(Previously Senior Director of Manufacturing Technical Services (MSAT), Genzyme)
Abstract Use of a perfusion bioreactor is one of the dominant operation modes in animal cell culture at commercial scales. This article provides an overview of cell retention technologies, and assesses the advantages and disadvantages of the perfusion process as compared to the fed-batch process. St...
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