Addressing delivery of poorly water-soluble compounds with an integrated science based approach
Posted on October 17, 2013
By: Shoufeng Li, Director, Technical Project Leader
Novartis
Oral absorption of poorly water soluble compounds has been the subject of intensive research for the last two decades, the emergence of high-throughput screening, new pharmacological target and subsequent medicinal chemistry effort have produced many NCEs with challenging physico-chemical properties...
To read the full article and other articles in this issue, please register for a free account or log in.
We will not sell or give your information to a third party. See our Privacy Policy
Related Topics and Keywords
amorphous region, biorelevant indicator, capsules, cocrystal, crystallisation, dissolution rate, drug loading, Emend, GI transit, high-throughput screening, human pharmacokinetic data, Intelence, Kaletra, lipid system, low aqueous solubility, MegaceES, melt extrusion system, microemulsion, micronization, milling process, molecules matrix, nano-particle approach, NCEs, Novartis, permeability, physico-chemical properties, polymer, poorly water-soluble compounds, powder in bottle (PIB), powder in capsule (PIC), Rapamune, Rezulin, salt forms, solid dispersion, solidified mircoemulsion, solubility, Sporanox, Spray-drying, stabiliser, surfactant, toxicity, TriCor 145
Subscribe to our FREE newsletter and WEBINAR UPDATES
We will not sell or give your information to a third party. See our Privacy Policy
