RAPID DETECTION OF COUNTERFEIT AND SUBSTANDARD MEDICINES WITH HANDHELD RAMAN

• Results in the field, in seconds
• Measure a wide range of material types

COUNTERFEIT SCREENING USING RAMAN ANALYSIS

Counterfeit pharmaceuticals are a global problem and include not only products containing potentially harmful substances, but also products that contain no or diluted amounts of active pharmaceutical ingredients (API). Because of this growing problem, the need for fast and easy screening techniques in the field has become increasingly urgent. Handheld Raman spectroscopy provides regulatory enforcement agencies the ability to examine the chemical composition of authentic products on the spot, resulting in rapid identification of counterfeits and immediate removal from the supply chain.

 

The new generation in handheld Raman analysis that streamlines your material ID workflow.

 

MINIMIZE FLUORESCENCE WHILE MAXIMIZING EFFICIENCY

Fluorescence interference is a challenge in detecting counterfeit drugs with handheld Raman analyzers using 785nm laser excitation sources. With a higher excitation wavelength generated by the handheld Rigaku ProgenyTM 1064nm analyzer, signal blocking fluorescence is minimized. To demonstrate the advantages of the use of a 1064nm analyzer, samples were analyzed with 1064nm and 785nm spectrometers (Figures 1-3). In all cases, excitation at 785nm yielded a strong fluorescence background precluding comparison of authentic and counterfeit products. In contrast, 1064nm spectra produced compound specific “signature” Raman peaks used to clearly distinguish between authentic and counterfeit products. Figure 3 shows a comparison of spectra obtained from a coated tablet with those from the core of tablet. It is clear that the 1064nm excitation Raman analyzer can measure the tablet through the coating and see peaks that are specific to the API.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Progeny 1064nm Advanced Analysis Technology

• Expands the list of identifiable materials

• Distinguishes between authentic and counterfeit products

• Accurately analyzes materials through packaging

Corporate Headquarters

Boston, MA USA; Tokyo, Japan

Manufacturing

Tucson, AZ USA

Corporate Sales Offices

Baltimore, MD USA; Hong Kong, China; Helsinki, Finland; Munich, Germany

Local distributors worldwide

Rigaku Raman Technologies, Inc.

Toll Free: +1 855.785.1064

Direct: +1 781.328.1024

Email: info@rigakuraman.com

www.rigakuprogeny.com

 

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Related Topics and Keywords

active pharmaceutical ingredients, API, Counterfeit detection, handheld Raman, Raman, Rigaku