Charles River Laboratories International has advanced their innovation and combined to launch the Endosafe TrilliumTM rCR cartridge offering. Expanding its robust bacterial endotoxin testing portfolio with a new animal-free testing solution, this offering, which builds on Charles River’s existing Trillium rCR vial product, enhances testing efficiency and accelerates manufacturing timelines while simultaneously contributing to Charles River’s 4Rs imperatives and further progressing our clients goals on sustainability and animal welfare.

The rCR cartridges are pre-loaded with all the reagents required to perform an endotoxin test, eliminating need for preparation of multiple reagents, and reducing the opportunity for technician error. Additionally, the product is fully aligned and integrated with Charles River’s existing suite of Endosafe cartridge instrumentation and software, allowing for current limulus amebocyte lysate cartridge clients to transition seamlessly.

The Trillium rCR formulation within the cartridge technology detects and quantifies natural environmental endotoxins by simulating the LAL enzymatic cascade through an optimized formulation and composition of three recombinant proteins and a specific concentration of key components. Our extensive data package supporting our proprietary matrix demonstrates assay superiority in accuracy, comparability, and robustness.

The Trillium cartridge was developed following a data-driven decision-making process to create a product that ultimately will provide the highest quality results among recombinant technologies and ensure patient safety. Samples representing a wide group of product types from global geographies were tested through a beta study of existing cartridge clients. The results for these samples showed equivalency within that data set, supporting the claim of equivalency to LAL.