Online monitoring, advanced control and operation of robust continuous pharmaceutical tablet manufacturing process
Posted on October 17, 2013
By: Fernando Muzzio, Professor; Ravendra Singh, Senior Post Doctoral Associate; Abhishek Sahay, Doctoral Student; Sarang Oka, Graduate; Rohit Ramachandran, Assistant Professor; Marianthi G. Lerapetritou, Professor; Xue Liu, Assistant Research Professor Rutgers University
Introduction Currently, pharmaceutical companies are facing several challenges because of high cost and lengthy time involved in new drug product development (approx. $1.2 billion; 10-15 years)1-2, reduced effective patent life, higher regulatory constraints and relatively inefficient QBT (Quality ...
To read the full article and other articles in this issue, please register for a free account or log in.
Related Topics and Keywords
A simulation-based closed-loop process performance, Advanced control strategy and architecture of the control platform, API concentration, blend composition measurement, content uniformity of the tablets, continuous manufacturing process, continuous pharmaceutical manufacturing process, continuous pharmaceutical tablet manufacturing process, Continuous tablet manufacturing, Continuous tablet manufacturing pilot plant, control, control hardware, control strategy and architecture of the control platform, data management tool, direct compaction, dry granulation, flexible continuous tablet manufacturing process, gravimetric feeders, hybrid MPC-PID strategy, manufacturing process, Model Predictive Control MPC, modular flowsheet model, modular flowsheet model of a flexible continuous tablet manufacturing process, moisture content of disintegrant, Multivariate analyses Tool, National Science Foundation Engineering Research Center on Structured Organic Particulate Systems, NIR spectroscopy, NIR spectroscopy for continuous monitoring of blend composition., Online monitoring, OPC communication protocol, operation, PAT, PAT data management tool, powder blend, Proportional Integral Derivative PID, QBT (Quality by Testing), real time release (RTR), reflectance based NIR spectroscopy, Reflectance based NIR spectroscopy for continuous monitoring of blend composition., robust continuous pharmaceutical manufacturing process, robust continuous pharmaceutical tablet, roller compaction, Rutgers University, simulation software, tablet manufacturing, tablet press hopper, tablet press., wet granulation
Related Product Videos
Related ProductsThe JDSU MicroNIR™ Spectrometer
SIMCA-online - ensuring product quality – Umetrics
Subscribe to our FREE newsletter and WEBINAR UPDATES