Employing Hot Melt Extrusion As a Cost Effective Method of Increasing Solubility Of Water Insoluble API’s


07th May 2019 | 9:00 am EST/ 14:00 GMT/ 15:00 CET | Dennis Douroumis, Professor in Pharmaceutical Technology and Process Engineering at University of Greenwich and Dirk Leister, Leader Technical Marketing at Thermo Fisher Scientific |BOOK FREE SEAT

• Identifying the appropriate excipients for HME processing of water insoluble drugs
• Using novel excipients to achieve increased dissolution rates (Granulation)
• Extrusion with polymeric carriers for the development of solid dispersions
• Co-crystallisation of water insoluble drugs

In the last 20 years Hot Melt Extrusion (HME) has seized the attention of pharmaceutical industry for the development of pharmaceutical solid dispersions. It is a versatile processing technology, which can effectively increase the solubility/dissolution of water insoluble active pharmaceutical ingredients (APIs). The processing of a wide range of materials including inorganic excipients, hydrophilic polymers or cocrystal formers renders HME advantageous compared to conventional formulation technologies. In this review article we discuss recent trends for increased solubility/dissolution of water insoluble actives by using HME and predictive tools for process optimisation.

Presented by Dennis Douroumis, Professor in Pharmaceutical Technology and Process Engineering at University of Greenwich


Dr. Dennis Douroumis is a Professor in Pharmaceutical Technology and Process Engineering at the Universities of Kent and Greenwich. His research focuses on the development and characterization of drug products by using continuous manufacturing processes such as hot melt extrusion and spray-drying. His research also explores the use of Quality by Design (QbD) approaches and Process Analytical Tools (PAT) for process optimization. He has industrial experience on R&D of solid dosage forms, technology transfer and scale-up. Due to his expertise he led several EU funded projects (MultiDES) as the principal investigator and he has established industrial collaborators for the development of extruded products. He is the Head of Medway School of Pharmacy and has joined the Editorial Boards of more than ten international peer reviewed journal including the Wiley’s Editorial Board for the series in “Advances in Pharmaceutical Technology”. He has published more than 120 peer-reviewed publications, including 100 full papers, 4 book chapters and 2 books (Wiley-Blackwell)

Sponsored by Thermo Fisher Scientific

Thermo Fisher Scientific provides reliable extrusion and granulation solutions in pharmaceutical processing. We can help you switch from batch to continuous processing with twin-screw extrusion technology and analytical expertise, and we give scientific support for scale-up of such operations. Our wide range of extruders and granulators, plus our rheometer systems, can help you meet goals faster.

Dirk Leister, Leader Technical Marketing at Thermo Fisher Scientific

Dirk_Leister_smallDirk Leister is the head of the application team for extruders and compounders at Thermo Fisher Scientific in Karlsruhe, Germany. The team focuses on applications for extrusion-based processes used in the pharmaceutical, food, and polymer industries. Dirk holds an engineering degree in biotechnology and started his professional career in pharmaceutical research and development. After moving to the instrument manufacturing side of the industry, he had several positions in technical sales and product management. His expertise is developing applications for process equipment used to conduct formulation research, process development and manufacturing scale-up for pharmaceutical and bulk material handling. Dirk is adept at helping companies minimize optimization time, costs and efforts of their continuous process scale-up.

 


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