Predictable scaling in single-use bioreactor format – GE Healthcare Life Sciences

Xcellerex™ XDR bioreactor systems are designed to deliver scalable process equivalence from 4.5 L to 2000 L working volume, in GMP environments. The system design is based on the same foundational principles as conventional stainless steel bioreactors. Consistent vessel geometries, tight relationship between consumables and equipment features, and a host of accessories combine for an easily scalable, single-use product line. Traditional scaling methodology, based on measures such as shear, tip speed, power per unit volume, kLa, and specific process sensitivities, can be used during scale-up. Technology transfer using the XDR systems is straightforward, minimizing the need for costly and time-consuming process redesign. The XDA bioreactor bag assembly is disposed after culture termination and eliminates costly and time-consuming cleaning-in-place and steam-in-place operations. The XDA bag assembly is prepackaged with a low profile impeller, a variety of sparge components, filters, and tubing, for quick and hassle-free installation. The flexibility of single-use technology enables quick changeover between productions, for efficient equipment utilization. The modular design of the XDR product line creates a process-ready system upon delivery and also supports integration into a user-preferred automation platform. Learn more at www.gelifesciences.com/BioProcess

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