Improved Process Understanding and End-Point Determination of High Shear Wet Granulation Process Using In-Line NIR at Different Scales
Posted on January 27, 2014
By: Hua Ma, Senior Development Scientist, GSK; Yu-E Zhang, Senior Manager, Ferring Pharmaceuticals; Hung Tian, Technical Development Leader, Novartis; Hitesh Chokshi, Ph.D., Senior Research Director, Hoffmann-La Roche
Introduction High-shear wet granulation is a fundamental pharmaceutical unit operation routinely used in solid dosage form development and manufacturing to enhance granule density, content uniformity, and final blend flowability and compressibility for downstream tablet or capsule production. As co...
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Related Topics and Keywords
FDA, GSK, High Shear Wet Granulation, Hoffmann-La Roche, In-Line NIR, NIR, Novartis, PAT, QbD, Raman
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